Cholesterol test for T cells

Cholesterol Metabolism in T Cells

Compartmentalization and spatial control of biochemical reactions is the foundation of cell-based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps them separate from the environment but also provides a platform for key receptors to sense and interact with outside factors. Arguably one of the cell types most reliant on interactions of this kind, immune cells dep...

Stem cells get a cholesterol test

I n addition to responding to changes in their local microenvironment, stem cells are regulated by systemic changes, such as the availability of nutrients in an organism's diet. In Drosophila, for example, egg production—which relies on the proliferation of both germline stem cells (GSCs) and follicle stem cells (FSCs)—is switched off when food is scarce and reactivated when conditions improve ...

Application of T-shape Friction T test for Ti-6Al-4V Alloy at Elevated Temperatures

There are several parameters that have significant influence in metal forming process. One of the most important of them is friction coefficient. Friction can change the pattern of metal flow and the force needed for deformation. It is necessary to determine the friction coefficient to study the effect of friction on metal forming process. This study is concerned with numerical and experimental...

Design and development of CAR-T cells for cancer therapy

Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...

Adult Thymus: A Forgotten Jail for Autoreactive T Cells